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Study ID RFH FH Study
Roby Rakhit,   University College Hospital and Royal Free Hospital
Title Atherosclerosis in Familial Hypercholesterolemia
Conditions Familial Hypercholesterolemia
Interventions Other: CT coronary angiogram and carotid ultrasound
Phase N/A
Purpose Familial hypercholesterolemia (FH) is a common inherited disorder with a frequency of 1 in 500 in the UK. Our aim is compare the carotid and coronary artery atherosclerosis in monogenic FH and polygenic hypercholesterolemia with means of a carotid ultrasound, a coronary CT angiogram and biochemical biomarkers.
Eligibility Ages Eligible: 18 Years
Genders Eligible:  Both
Accepts Healthy Volunteers:  Accepts Healthy Volunteers
Inclusion Criteria:
  • The subjects must give written informed consent to participate in the study, Male and female subjects ≥ 18 years old, documentation of clinical diagnosis of familial Hypercholesterolemia Exclusion Criteria:
  • Estimated GFR <45, pregnant women, Atrial fibrillation or unstable heart rate, Established ischemic heart disease, previous Percutaneous Coronary Investigations (PCI) or Coronary Artery Bypass Surgery (CABG), Known allergy to iodine contrast
  • Study Location N/A
    Contact Roby Rakhit
    020 7794 0500
    Information obtained from, on 7/4/2015. For additional information about this and other clinical trials, visit
    Please refer to this study by its identifier: NCT02489253

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