Research / Clinical
Summary
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Diseases/Research Topics
CAD
The Insel laboratory has a long-standing interest in signal transduction mechanisms, in particular by G-protein-coupled receptors (GPCRs).
For the past 30 years, a main system of interest has been the murine T-lymphoma cell line, S49, with its large number of somatic cell mutants in the pathways of GPCR and steroid-hormone action. In recent years, they have focused on mechanisms by which those two classes of receptor systems regulate cell cycle (G1) arrest and apoptosis. Recent work shows a possible convergence mechanisms involved in apoptosis by the two hormonal systems with confirmatory data in human T-cell lymphoma, as well.
Current work involves use of DNA microarrays to define the networks of genes (and ultimately proteins) that mediate cell cycle arrest and apoptosis in lymphoma cells. In parallel, distinct studies they have uncovered novel mechanisms for anti-apoptosis in human colon cancer cells and are conducting studies to determine mechanism and frequency of the target gene/protein, cellular inhibitor of apoptosis protein 2 (cIAP2) that they identified.
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