Research / Clinical
Summary
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Diseases/Research Topics
Array, Cancer, CGH, Deletions, Melanoma, Mouse, Ras, RTKs, Skin Cancer, Sprouty, Transgenic
Dr. Yu's lab studies how antagonists of receptor tyrosine kinase (RTK) signals called Sprouty genes regulate cellular processes in the skin and in cancers of the skin (such as squamous cell carcinoma and melanoma). They are studying how Sproutys block RTK signals and what proteins regulate Sproutys intracellularly and transcriptionally.
The lab uses Sprouty-deficient models to study how changes in RTK signals affect the development of different cancer subtypes, frequency, and behavior. In a related research program, the laboratory uses transgenic models, array comparative genomic hybridization (array CGH), and fluorescent in situ hybridization (FISH) technologies to identify additional genes that execute or regulate responses to RTK signals.
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