Palliative Care Clinical Trials

Our team is dedicated to clinical research in the field of palliative care. For more information on any of these trials, or to find out if you're eligible to participate, contact Carolyn Revta, Palliative Care Clinical Research Operations Director, crevta@ucsd.edu or 858-822-3614.

Ongoing Studies

PledPharma PP095–PLIANT

Status: Currently recruiting
ClinicalTrials.gov identifier: NCT01619423
Eligible: Patients with metastatic colorectal cancer
The first line of treatment for patients with metastatic colorectal cancer is the combination chemotherapy FOLFOX (5–Fluorouracil, Leucovorin and Oxaliplatin), which is given as an intravenous (IV) infusion every two weeks. Although very effective in treating colorectal cancer, there are a number of side effects associated with this treatment regimen, including decreased white blood cell counts, sensory neuropathy of the hands and feet, and diarrhea. These side effects significantly impact a patient’s ability to tolerate treatment with FOLFOX and often result in dose reduction, dose delays, or early progression to a second line of chemotherapy. PledOx is an experimental drug designed to reduce the incidence and severity of these treatment related side effects. PledOx is a manganese-based treatment designed to reduce the toxic effects of chemotherapy in healthy cells. The goal of this open label phase II study is to assess the efficacy of two different doses of PledOx vs. placebo in protecting against side effects associated with the administration of FOLFOX in patients with metastatic colorectal cancer.

Positive Support in Cancer Care: Emphasizing Quality of Life and Legacy

Status: Currently recruiting
Eligible: Cancer patients who are eligible for or are currently receiving hospice or palliative care
This study focuses on the positive outcomes of providing cancer patients with extra support and attention. Patients included in this study will receive extra support from trained clinicians over the course of approximately two weeks. There will be two groups in the study. One group will be focused on support through storytelling and the creation of a life story (legacy) document. The second group will be focused on general support for daily needs or concerns. The primary goal of this study will help researchers understand the impact of different types of psychosocial support and how this process may positively impact people's well-being and quality of life.


Contact

Carolyn Revta
Palliative Care Clinical Research Operations Director
Moores Cancer Center
crevta@ucsd.edu
Phone: 858-822-3614