Associate Director for Innovation and Industry Alliances David Cheresh
David Cheresh, PhD
Distinguished Professor of Pathology
David A. Cheresh is a leading authority in the study of angiogenesis – the growth of new blood vessels tumors need to grow. Since coming to UC San Diego Moores Cancer Center in 2005, Cheresh has led efforts to develop new collaborations and programs in clinical and basic science with an emphasis on translational medicine. He is Associated Director for Innovation and Industry Alliances, Vice Chair of Pathology, co-director of the Solid Tumor Therapeutics Program and a Distinguished Professor.
Dr. Cheresh studies the signaling networks that regulate angiogenesis, tumor growth, drug resistance and metastasis. He identified that integrin ανβ3 – a receptor on the surface of tumor-associated blood vessels – as a critical biomarker of angiogenesis. He successfully translated laboratory discoveries into biologically-based drugs that are now in various stages of clinical development. Cheresh’s research is widely published, with seven papers cited more than 1,000 times each. Most recently, Cheresh and colleagues have created a novel scaffold-based chemistry approach to stabilize kinases – growth-signaling enzymes – in their inactive state. These studies have led to the development of a first-in-class Raf inhibitor that interferes with angiogenesis signaling pathways.
Dr. Cheresh received his doctorate in immunology from the University of Miami School of Medicine. He is the recipient of numerous awards including the 15th Hans Linder Memorial Lecture from the Weizmann Institute of Science in Rehovot, Israel; the XXIII Annual Myron Karon Memorial Lectureship from the University of Southern California; the Robert Flynn Professorship Award from Tufts University School of Medicine; the Judah Folkman lectureship; and the Paget-Ewing award from the Metastasis Research Society/American Association for Cancer Research. He has a received both a American Cancer Society Faculty Research Award and a National Cancer Institute Merit Award.
David Cheresh, PhD
Executive assistant: Zoya Vigalok