Research / Clinical Summary

Webster Cavenee, PhD Professor, Medicine Cancer Biology Program Contact by Email

Other Leadership Roles:
Director, Ludwig Institute for Cancer Research

Our research entails identifying, characterizing and understanding the function of genetic lesions which occur during the initiation or progression of cancers of the brain, prostate, muscle or melanocyte. In the first area we have shown a dependence on unique combinations of growth factors for astrocyte transformation. In the second, we have shown that the cell cycle regulatory D1 cyclin directly complexes with the androgen receptor and inhibits its transcriptional ability. In the third, we have shown that a transcription factor involved in striated muscle tumors is regulated by growth factors through phosphorylation-dependant nuclear exclusion. In the fourth, we have shown that the common chromosome 10 monosomy occurring in melanomas results from the necessity of loss of two separate tumor suppressors on the long and short arms.

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