Research / Clinical
Summary
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Diseases/Research Topics
Chemical Biology, Mass Spectrometry, Therapeutic Agents
The Dorrestein lab is developing mass spectrometric and chemical biology tools to harvest the therapeutic potential of orphan microbial gene clusters. About 50% of all anti-cancer agents are natural products or natural product derived. Taxol, Mylotarg are two examples of such natural products.
The Dorrestein lab uses hypothesis-driven proteomic strategies to establish the function of proteins found on orphan gene clusters. By establishing the function of the proteins, they gain insight into the natural product that is produced by this gene cluster.
The lab's current efforts are aimed at finding aldehyde inhibitors. Each of the aldehyde natural products that have been found to target important cellular targets (e.g. caspases, cathepsin or the ubiquitination pathway). Therefore, any new aldehyde inhibitor may reveal a new target. To identify the target for these aldehyde inhibitors, the lab is also developing novel probes for matrix free MALDI-imaging to localize the position of these proteases such as caspases on histological preparations.
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