Research / Clinical Summary

Ronald Evans, PhD Professor, Biological Sciences Contact by Email Visit the Website

Our lab studies receptors that serve as transcriptional sensors for steroid, retinoid and thyroid hormones. Thus, estrogens, androgens, and glucocorticoids, all of which contribute to various aspects of the progression and treatment of human cancers, act through various members of this receptor superfamily. The vitamin A receptor is the target for retionic acid and a number of retinoid related drugs that are used in the treatment of a variety of leukemias, skin cancers, and oral leukoplakia.

We specifically examine the role of these receptors in breast cancer, prostate cancer, colon cancer, as well as in certain hematopoetic disorders such as acute promyelocytic leukemia (APL). Our lab has created a number of transgenic and knockout mouse models to better understand the role of nuclear receptors in etiology and treatment of human disease.

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