Research / Clinical
Summary
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Diseases/Research Topics
Hematopoesis, Leukemogenesis, Mouse, Mouse Models, Zebrafish
Dr. Traver and his group are interested in vertebrate blood cell development, with an emphasis on the hematopoietic stem cells (HSCs) that produce all cells of the hematolymphoid system. The hallmarks of HSCs are the abilities to generate multiple blood cell lineages, to self-renew, and to proliferate without apparent limit.
Interestingly, the latter two hallmarks are shared by cancer cells. In mouse and zebrafish models of leukemia, we are studying the cancer stem cells that underlie propagation of disease. Their ultimate goals are to understand the biology of both normal and cancer stem cells to dissect the genetics of self-renewal and perhaps target the root of leukemogenic transformation.
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