Research / Clinical
Summary
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Christopher Glass, MD, PhD
Professor, Medicine / Cellular & Molecular Medicine
Cancer Biology Program
Contact by Email
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Diseases/Research Topics
Gene Expression
Dr. Glass’ laboratory investigates the mechanisms by which sequence-specific transcription factors regulate the development and function of macrophages. A major focus is on members of the nuclear receptor, AP-1 and Ets families of transcription factors.
Studies over the past few years have led to the identification of a large number of coactivator and corepressor complexes that interact with these factors in a ligand or signal-dependent manner and mediate their transcriptional effects.
Current efforts are to determine the biochemical and biological roles of these transcription factors and their associated co-regulators in controlling macrophage differentiation and function. A combination of biochemical, cellular and genetic model systems are used, incorporating macrophage-specific knockouts, microarray technologies and bioinformatics approaches, to unravel the contributions of specific factors to the development of specialized macrophage functions in immunity and the pathogenesis of inflammatory diseases.
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