Research / Clinical
Summary
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William Wachsman, MD, PhD
Associate Professor IR, Medicine
Tumor Growth, Invasion & Metastasis Program
Contact by Email
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Diseases/Research Topics
AIDS, Autoimmune Disease, Cancer, HIV, HTLV, Human Retroviruses, Leukemia, Leukemias and Lymphoma, Lymphoma, Prostate Cancer
In March 2003, Dr. Wachsman, a clinician-scientist with strong credentials in retroviral research, took over as site principal investigator of the AIDS Malignancy Consortium (AMC).
No newcomer to HIV, Dr. Wachsman has been involved in human retroviral research for more than two decades. His research fuses basic molecular studies and translational genomics with clinical investigation. He was the first to identify the existence of a retroviral accessory gene product, tax (then termed X) in the human T-cell leukemia virus genome. Subsequently, his investigations at UCLA and UCSD delineated the critical nature of Tax protein within the HTLV lifecycle, its mode of action, and its potential role in the pathogenesis of HTLV-induced adult T-cell leukemia/lymphoma (ATLL).
Wachsman’s translational research on HTLV identified a second isolate of HTLV-II associated with hairy cell leukemia and developed a murine hu-SCID model of ATLL. With regard to HIV, his collaborative investigations with Dr. Martin Lotz at The Scripps Research Institute addressed the role of the cytokines, transforming growth factor-b1 (TGFb1, interleukin-6, and leukemia inhibitory factor (LIF), in HIV-induced T- and B-cell immunopathogenesis, the mechanisms of HTLV-associated myelopathy, and the genes involved in the progression of ATLL.
More recently, Wachsman has developed a research program to characterize molecular biomarkers of various cancers, including lymphoma and prostate. He is a frequent ad hoc reviewer for the Journal of Virology, JAIDS, and Blood. He also heads the Moores UCSD Cancer Center Microarray Shared Resource.
Wachsman sees or consults on many of the HTLV-infected patients in the San Diego locale. His contribution to the AMC is primarily in the area of translational research, with a focus on pharmacogenomics to identify biomarkers predictive of disease biology and treatment response.
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