Research / Clinical
Summary
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Lawrence Goldstein, PhD
Professor, Cellular & Molecular Medicine
Cancer Genetics Program
Contact by Email
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Diseases/Research Topics
Leukemia
We are interested in using human embryonic stem cells to prospectively test whether mutations detected in human cancers are sufficient to drive differentiated human cells to a cancer stem cell fate.
At present, we are focused on chronic myelogenous leukemia, CML, a form of leukemia where there is a clear genetic hypothesis about what genetic changes convert a hematopoietic precursor to a leukemia stem cell. If we can reproducibly generate leukemia stem cells, this work may allow testing of new drugs, development of new diagnostics, and better understanding of the molecular changes caused by mutations that cause the cancer stem cell fate.
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