Research / Clinical
Summary
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Diseases/Research Topics
Animal Models, Cancer, Colorectal Cancer, Immunology, Inflammatory Bowel Disease, Mucosal Immunology
Dr. Eckmann's laboratory studies the impact of intestinal inflammation on the development of colorectal cancer. Inflammation is a normal host response to infection with disease-causing microbes in the intestinal tract and other organs, and is required for clearance of such microbes. In patients suffering from inflammatory bowel disease (IBD), inflammation occurs in the apparent absence of microbial infection for extended periods. IBD patients have a markedly increased life-time risk of developing colorectal cancer, which indicates that long-standing intestinal inflammation promotes cancer development.
His studies employ rodent models of intestinal inflammation and cancer to define the mechanisms by which inflammatory processes are regulated in the intestinal tract and how they can promote cancer development in that organ. Insights from these studies will help us to develop new pharmacological strategies to prevent the development of colorectal cancer in IBD patients.
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