Research / Clinical
Summary
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Gordon Saxe, MD, PhD
Assistant Adjunct Professor, Family & Preventive Medicine
Cancer Prevention & Control Program
Contact by Email
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Diseases/Research Topics
Cancer, Clinical Trials, Clinical Trials Development, Diet, Prostate Cancer, Stress, Stress Reduction
Dr. Saxe's research focuses on the role of diet and lifestyle in cancer prevention and treatment, specifically whether dietary modification (increased whole cereal grains and vegetables, decreased saturated fat), reinforced by stress management training, can attenuate progression of biochemically recurrent prostate cancer.
This question is being addressed in a small randomized clinical interventional trial that is now underway. The primary outcome measure is change from baseline in log slope prostate specific antigen, the strongest single predictor of overall survival in patients with recurrent prostate cancer. Secondary intervention outcomes include changes in intermediate biomarkers (sexsteroid hormones such as testosterone, DHT, estradiol, and SHBG; cytokines such as IL-6, TNF-alpha; and other markers of tumor metastasis and apoptosis), dietary intakes of selected nutrients, foods, and food groups, anthropometric status (weight, BMI, waist circumference, body composition), serum lipids, and quality of life.
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