Research / Clinical
Summary
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Antonio De Maio, PhD
Professor & Vice Chairman of Research, Surgery
Cancer Biology Program
Contact by Email
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Diseases/Research Topics
Heat Shock Proteins
Dr. De Maio focuses on the expression of genes encoding heat shock or stress proteins, the first line of cellular defense. The presence of these proteins confers protection to cells from subsequent stresses, a phenomenon coined stress tolerance.
Heat shock proteins are found on the surface of many cancer cells and are secreted into circulation in a membrane-bound form. These secreted heat shock proteins can modulate the immune system and affect the response of transformed cells. The mechanism of release and activation of the immune system by secreted heat shock proteins is currently being investigated by the De Maio laboratory.
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