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SHARED
RESOURCES - Medicinal Chemistry
- Leader:
- Wolf Wrasidlo Ph.D.
- Senior Project Scientist
- (858) 534-7080
- wwrasidlo@ucsd.edu
- Contact:
- See above
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- Service Profile:
- • Organic synthesis of small molecules, in house, or through other sources
- • Library design for virtual screening studies and SAR profiling
- • Pre-clinical assessment of compounds for biostability and drugability
- • Formulation of compounds for pharmaceutical studies
- • Assistance with pre-clinical data generation and interpretation, including cell based and in vivo efficacy testing.
- Equipment:
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Gleason Preparative HPLC for compound purification
- Agilent LC/Mass Spectrometer
- NMR Spectrometer
- Overview of the Shared Resource:
- This resource provides support for investigators who have conceived new strategies that involve the use of organic compounds for medical use. The service offers in-house expertise to produce such agents from the design stage though the synthesis and characterization on a non-GMP basis. In addition, the resource can formulate compounds for preclinical investigations and lends expertise in the pharmaceutical assessment, including protein binding, metabolic stability and bioavailability.
A research service of the NCI-designated
Moores UCSD Cancer Center: http://cancer.ucsd.edu
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